What is Zoloft? Zoloft (Sertraline) belongs to a class of antidepressants called selective serotonin reuptake inhibitors (SSRIs). It works by increasing the amounts of serotonin, a natural substance in the brain that helps maintain mental balance. Sertraline is used to treat depression, obsessive-compulsive disorder (bothersome thoughts that won’t go away and the need to […]