Definition: A constellation of features said to be associated with substance use, including apathy, loss of effectiveness, diminished capacity to carryout complex or long-term plans, low tolerance for frustration, impaired concentration, and difficulty in following routines. The existence of this condition is controversial. It has been reported principally in connection with cannabis use, and may simply reflect chronic cannabis intoxication. The symptoms may also reflect the user’s personality, attitudes, or developmental stage.